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Ifosfamide in the elderly: clinical considerations for a better drug management.

Authors
  • De Pas, T
  • Curigliano, G
  • Catania, C
  • Comandone, A
  • de Braud, F
Type
Published Article
Journal
Critical Reviews in Oncology/Hematology
Publisher
Elsevier
Publication Date
Feb 01, 2000
Volume
33
Issue
2
Pages
129–135
Identifiers
PMID: 10737374
Source
Medline
License
Unknown

Abstract

The therapeutic strategy used for elderly affected by malignant neoplasms should take into account the common variables present in oncological patients, and the specific alteration of the elderly metabolism and their possible morbidity. Ifosfamide is an active drug for various tumors with elevated incidence in the elderly. We analyze the principle criteria in the selection of these patients and the alterations of metabolism which correlates to aging with their consequences on the pharmacokinetics of ifosfamide. Finally, we propose clinical guidelines to optimize the use of ifosfamide in elderly patients affected by malignant tumors.

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