Affordable Access

Access to the full text

The IFN-Ɣ + 874 A/T polymorphism is associated with malignant breast cancer in a population from the southwest of Iran

Authors
  • Rezaeean, Hadi1
  • Kaydani, Gholam Abbas2
  • Saki, Najmaldin2
  • Razmjoo, Sasan2
  • Labibzadeh, Maryam2
  • Yaghooti, Hamid2
  • 1 High Institute for Education and Research in Transfusion Medicine, Tehran, Iran , Tehran (Iran)
  • 2 Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , Ahvaz (Iran)
Type
Published Article
Journal
BMC Research Notes
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Apr 20, 2021
Volume
14
Issue
1
Identifiers
DOI: 10.1186/s13104-021-05543-6
Source
Springer Nature
Keywords
License
Green

Abstract

ObjectiveBreast cancer (BC) is one of the most common diseases in women globally, with an increasing number of deaths associated with it. Recently the role of polymorphisms in the genes encoding cytokines and immune cells has been demonstrated. This study aimed to evaluate the association of IFN-Ɣ + 874 A/T polymorphism with BC clinical symptoms.ResultsThe study included 88 women with BC and 88 healthy women who had no history of cancer and were matched for age and sex. Allele-specific oligonucleotide-polymerase chain reaction technique was used to investigate the IFN-Ɣ polymorphism. Clinical data were obtained from the patients’ records. Our results showed that the frequencies of genotypes in the BC patients were not significantly different from the control subjects. However, in the patients, the AT genotype was associated with the risk of malignant BC. The age at BC diagnosis was not different in patients with AA and AT genotypes; however, it was significantly earlier in HER2 negative subjects (p = 0.002). Given the higher frequency of AT in malignant BC patients, our results confirm the association of the IFN-Ɣ polymorphism with the disease’s progression to a malignant state.

Report this publication

Statistics

Seen <100 times