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'Idiopathic' eosinophilia with an Occult T-cell clone: prevalence and clinical course.

Authors
Type
Published Article
Journal
Leukemia Research
0145-2126
Publisher
Elsevier
Publication Date
Volume
31
Issue
5
Pages
691–694
Identifiers
PMID: 17095087
Source
Medline

Abstract

In a study of 99 consecutive patients with "idiopathic" eosinophilia, clonal T-cells were demonstrated in blood, bone marrow, or other tissue samples of 14 patients including 6 who had an overt T-cell malignancy. The remaining eight patients (approximately 8%) with an "Occult" T-cell clone had predominantly cutaneous disease and FIP1L1-PDGFRA was absent in all six evaluable patients. Two patients were effectively treated with low-dose oral cyclophosphamide or methotrexate whereas Gleevec treatment was ineffective in another two patients. Two patients (25%) transformed into cutaneous T-cell lymphoma after 3-8 years of eosinophilic prodrome.

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