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Identifying adverse drug reactions associated with drug-drug interactions: data mining of a spontaneous reporting database in Italy.

Authors
  • Leone, Roberto
  • Magro, Lara
  • Moretti, Ugo
  • Cutroneo, Paola
  • Moschini, Martina
  • Motola, Domenico
  • Tuccori, Marco
  • Conforti, Anita
Type
Published Article
Journal
Drug safety
Publication Date
Aug 01, 2010
Volume
33
Issue
8
Pages
667–675
Identifiers
DOI: 10.2165/11534400-000000000-00000
PMID: 20635825
Source
Medline
License
Unknown

Abstract

This study validates that spontaneous reporting, despite its limitations, can be an important resource for detecting ADRs associated with the concomitant use of interacting drugs. Moreover, our data confirm that DDIs could be a real problem in clinical practice, showing that more than one in five patients exposed to a potential DDI experienced a related ADR.

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