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Identification of the Vibrio vulnificus wbpP gene and evaluation of its role in virulence.

Authors
  • Park, Na Young
  • Lee, Jeong Hyun
  • Kim, Myung Won
  • Jeong, Hee Gon
  • Lee, Byung Cheol
  • Kim, Tae Sung
  • Choi, Sang Ho
Type
Published Article
Journal
Infection and immunity
Publication Date
Jan 01, 2006
Volume
74
Issue
1
Pages
721–728
Identifiers
PMID: 16369029
Source
Medline
License
Unknown

Abstract

A wbpP gene encoding a putative UDP-N-acetyl-D-glucosamine C(4) epimerase was identified and cloned from Vibrio vulnificus. The functions of the wbpP gene, assessed by the construction of an isogenic mutant and by evaluating its phenotype changes, demonstrated that WbpP is essential in both the pathogenesis and the capsular polysaccharide biosynthesis of V. vulnificus.

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