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Identification of an oral microbiota signature associated with an impaired orosensory perception of lipids in insulin-resistant patients

Authors
  • Besnard, Philippe1, 2
  • Christensen, Jeffrey E.3
  • Bernard, Arnaud1
  • Simoneau-Robin, Isabelle1
  • Collet, Xavier3
  • Verges, Bruno1
  • Burcelin, Rémy3
  • 1 UMR 1231 Lipides/Nutrition/Cancer INSERM/Univ Bourgogne-Franche Comté/AgroSup Dijon,
  • 2 AgroSup Dijon,
  • 3 UMR 1048 INSERM/Univ Toulouse III Paul Sabatier,
Type
Published Article
Journal
Acta Diabetologica
Publisher
Springer Milan
Publication Date
Jul 16, 2020
Volume
57
Issue
12
Pages
1445–1451
Identifiers
DOI: 10.1007/s00592-020-01567-9
PMID: 32676702
PMCID: PMC7591415
Source
PubMed Central
Keywords
License
Unknown

Abstract

Aims Type 2 diabetes leads to multiple sensory dysfunctions affecting notably the gustatory sensitivity. Although this sensory defect, by impacting food choices, might lead to unhealthy eating behavior, underlying mechanisms remains poorly studied. We have recently reported that the composition of microbiota in contact with circumvallate gustatory papillae might affect the orosensory perception of lipids in lean and normoglycemic obese subjects. This finding has prompted us to explore whether such a phenomenon also occurs in diabetic obese patients. Methods The composition of microbiota surrounding the circumvallate papillae was analyzed in combination with the linoleic acid perception thresholds in male insulin-resistant patients and weight-matched healthy controls . Two complementary comparisons were performed: (1) controls vs diabetic and (2) diabetic low-lipid tasters versus diabetic high-lipid tasters. Results Despite subtle modifications in the oral microbiota composition, comparison of orosensory lipid perception in controls and diabetic subjects did not lead to discriminating data due to the large inter-individual variability of linoleic acid perception thresholds. In contrast, specific bacterial signatures were found by comparing diabetic low- and high-lipid tasters leading to differential molecular pathways. Surprisingly, a lower fatty taste perception was mainly found in patients treated with metformin and/or statins, suggesting a possible side effect of these antidiabetic and/or hypolipidemic drugs on taste acuity. Conclusions Collectively, these data show that the diabetic patients with defective fatty taste detection are characterized by a specific microbiota metabolism at the circumvallate papillae levels, this occurrence seeming amplified by drugs commonly used to counteract the damaging metabolic effects of T2D. Trial registration for original previous studies: ClinicalTrials.gov #NCT02028975

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