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Identification of novel genes coding for small expressed RNAs.

Authors
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Volume
294
Issue
5543
Pages
853–858
Identifiers
PMID: 11679670
Source
Medline

Abstract

In Caenorhabditis elegans, lin-4 and let-7 encode 22- and 21-nucleotide (nt) RNAs, respectively, which function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as small temporal RNAs (stRNAs). We show that many 21- and 22-nt expressed RNAs, termed microRNAs, exist in invertebrates and vertebrates and that some of these novel RNAs, similar to let-7 stRNA, are highly conserved. This suggests that sequence-specific, posttranscriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.

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