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Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution.

Authors
  • Steinman, R M
  • Cohn, Z A
Type
Published Article
Journal
The Journal of experimental medicine
Publication Date
May 01, 1973
Volume
137
Issue
5
Pages
1142–1162
Identifiers
PMID: 4573839
Source
Medline
License
Unknown

Abstract

A novel cell type has been identified in adherent cell populations prepared from mouse peripheral lymphoid organs (spleen, lymph node, Peyer's patch). Though present in small numbers (0.1-1.6% of the total nucleated cells) the cells have distinct morphological features. The nucleus is large, retractile, contorted in shape, and contains small nucleoli (usually two). The abundant cytoplasm is arranged in processes of varying length and width and contains many large spherical mitochondria. In the living state, the cells undergo characteristic movements, and unlike macrophages, do not appear to engage in active endocytosis. The term, dendritic cell, is proposed for this novel cell type.

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