Identification of the N-acetylcysteine conjugate of benzidine formed in the peroxidase activation system.
- Published Article
- Publication Date
Jan 01, 1985
Benzidine is oxidized by the peroxidase/H2O2 system, yielding reactive intermediates. In the presence of thiols, covalent adducts are formed. We used h.p.l.c. to separate the products of the reaction of benzidine with N-acetylcysteine. The major product was identified by n.m.r. spectroscopy (1H-n.m.r.) as 3-(N-acetylcystein-S-yl)-benzidine.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/3967336