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Identification and mapping of 26 human testis mRNAs containing CAG/CTG repeats.

Authors
Type
Published Article
Journal
Mammalian genome : official journal of the International Mammalian Genome Society
Publication Date
Volume
9
Issue
9
Pages
745–748
Identifiers
PMID: 9716660
Source
Medline

Abstract

Various types of pathologies, including neurodegenerative diseases, as well as different types of neoplasia, are related to genes exhibiting simple tandem repeat instabilities. In order to seek for new candidate genes for such disorders, we screened 4.10(6) human testis cDNAs for CAG- and CTG-containing clones. Among 910 positive clones, we characterized 109 cDNAs corresponding to 26 independent mRNAs. Fourteen of these mRNAs represent new genes. The corresponding clones contain between 3 and 19 consecutive CAG or CTG triplets. We assigned 15 out of these 26 genes to 14 different human chromosomes. These genes represent new potential candidates for diseases associated with CAG or CTG repeat mutations.

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