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[Identification of kinins releasing by pig pancreatic kallikrein from rabbit low molecular weight kininogen].

Authors
  • Paskhina, T S
  • Makevnina, L G
  • Egorova, T P
  • Levina, G O
Type
Published Article
Journal
Biokhimii︠a︡ (Moscow, Russia)
Publication Date
Jun 01, 1977
Volume
42
Issue
6
Pages
1144–1147
Identifiers
PMID: 889975
Source
Medline
License
Unknown

Abstract

Pig pancreatic kallikrein is found to release kinins from LMrK with the rate of 800 mkg. eq. of bradykinin per min, per 1 mg of the enzyme. This kininogenase reaction is not accompanied by a ddep fragmentation of the kininogen molecule, because only a high molecular weight fragment which Mr is practically equal to that of intact LMrK (55-60 000), and a peptide identified as bradykinin, are found in hydrolysate. In the same conditions human salivary kallikrein is found to form kallidin from LMrK.

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