Identification of a genetic risk factor for systemic juvenile rheumatoid arthritis in the 5'-flanking region of the TNFalpha gene and HLA genes.
- Published Article
Arthritis and rheumatism
- Publication Date
Dec 01, 1999
The -1,031C/-863A allele and the -857T allele of the TNFalpha gene, both of which are related to high production of tumor necrosis factor alpha, are associated with systemic JRA. The -857T allele may enhance the effect of the DRB1*0405/DQB1*0401 haplotype in predisposing to development of systemic JRA.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/10616003