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Identification of a genetic risk factor for systemic juvenile rheumatoid arthritis in the 5'-flanking region of the TNFalpha gene and HLA genes.

Authors
  • Date, Y
  • Seki, N
  • Kamizono, S
  • Higuchi, T
  • Hirata, T
  • Miyata, K
  • Ohkuni, M
  • Tatsuzawa, O
  • Yokota, S
  • Joo, K
  • Ueda, K
  • Sasazuki, T
  • Kimura, A
  • Itoh, K
  • Kato, H
Type
Published Article
Journal
Arthritis and rheumatism
Publication Date
Dec 01, 1999
Volume
42
Issue
12
Pages
2577–2582
Identifiers
PMID: 10616003
Source
Medline
License
Unknown

Abstract

The -1,031C/-863A allele and the -857T allele of the TNFalpha gene, both of which are related to high production of tumor necrosis factor alpha, are associated with systemic JRA. The -857T allele may enhance the effect of the DRB1*0405/DQB1*0401 haplotype in predisposing to development of systemic JRA.

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