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Identification of EGF-NF-κB-FOXC1 signaling axis in basal-like breast cancer.

Authors
  • Chung, Stacey1
  • Jin, Yanli1
  • Han, Bingchen1
  • Qu, Ying1
  • Gao, Bowen1
  • Giuliano, Armando E1
  • Cui, Xiaojiang2, 3
  • 1 Department of Surgery, Samuel Oschin Cancer Institute, Cedars-Sinai Medical Center, California, Los Angeles, 90048, USA.
  • 2 Department of Surgery, Samuel Oschin Cancer Institute, Cedars-Sinai Medical Center, California, Los Angeles, 90048, USA. [email protected]
  • 3 Cedars-Sinai Medical Center, Davis Research Building 2065, 8700 Beverly Blvd, California, Los Angeles, 90048, USA. [email protected]
Type
Published Article
Journal
Cell communication and signaling : CCS
Publication Date
Jun 19, 2017
Volume
15
Issue
1
Pages
22–22
Identifiers
DOI: 10.1186/s12964-017-0180-3
PMID: 28629477
Source
Medline
Keywords
License
Unknown

Abstract

Collectively, our findings reveal a novel EGFR-NF-κB-FOXC1 signaling axis that is critical for BLBC cell function, supporting the notion that intervention in the FOXC1 pathway may provide potential modalities for BLBC treatment.

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