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Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study

Authors
  • calvani, riccardo
  • rodriguez-mañas, leocadio
  • picca, anna
  • marini, federico
  • biancolillo, alessandra
  • laosa, olga
  • pedraza, laura
  • gervasoni, jacopo
  • primiano, aniello
  • conta, giorgia
  • bourdel-marchasson, isabelle
  • regueme, sophie c.
  • bernabei, roberto
  • marzetti, emanuele
  • sinclair, alan j.
  • gambassi, giovanni
Publication Date
Jan 12, 2020
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

Diabetes and frailty are highly prevalent conditions that impact the health status of older adults. Perturbations in protein/amino acid metabolism are associated with both functional impairment and type 2 diabetes mellitus (T2DM). In the present study, we compared the concentrations of a panel of circulating 37 amino acids and derivatives between frail/pre-frail older adults with T2DM and robust non-diabetic controls. Sixty-six functionally impaired older persons aged 70+ with T2DM and 30 age and sex-matched controls were included in the analysis. We applied a partial least squares-discriminant analysis (PLS-DA)-based analytical strategy to characterize the metabotype of study participants. The optimal complexity of the PLS-DA model was found to be two latent variables. The proportion of correct classification was 94.1 &plusmn / 1.9% for frail/pre-frail persons with T2DM and 100% for control participants. Functionally impaired older persons with T2DM showed higher levels of 3-methyl histidine, alanine, arginine, glutamic acid, ethanolamine sarcosine, and tryptophan. Control participants had higher levels of ornithine and taurine. These findings indicate that a specific profile of amino acids and derivatives characterizes pre-frail/frail older persons with T2DM. The dissection of these pathways may provide novel insights into the metabolic perturbations involved in the disabling cascade in older persons with T2DM.

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