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Identification of a Circulating Amino Acid Signature in Frail Older Persons with Type 2 Diabetes Mellitus: Results from the Metabofrail Study

Authors
  • Calvani, Riccardo1, 2
  • Rodriguez-Mañas, Leocadio
  • Picca, Anna1, 2
  • Marini, Federico3
  • Biancolillo, Alessandra
  • Laosa, Olga4
  • Pedraza, Laura4
  • Gervasoni, Jacopo1, 2
  • Primiano, Aniello1, 2
  • Conta, Giorgia3
  • Bourdel-Marchasson, Isabelle5
  • Regueme, Sophie C.5
  • Bernabei, Roberto1, 2
  • Marzetti, Emanuele1, 2
  • Sinclair, Alan J.
  • Gambassi, Giovanni1, 2
  • 1 (G.G.)
  • 2 Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, 00168 Rome, Italy
  • 3 (G.C.)
  • 4 (L.P.)
  • 5 (S.C.R.)
Type
Published Article
Journal
Nutrients
Publisher
MDPI AG
Publication Date
Jan 12, 2020
Volume
12
Issue
1
Identifiers
DOI: 10.3390/nu12010199
PMID: 31940925
PMCID: PMC7019630
Source
PubMed Central
Keywords
License
Green

Abstract

Diabetes and frailty are highly prevalent conditions that impact the health status of older adults. Perturbations in protein/amino acid metabolism are associated with both functional impairment and type 2 diabetes mellitus (T2DM). In the present study, we compared the concentrations of a panel of circulating 37 amino acids and derivatives between frail/pre-frail older adults with T2DM and robust non-diabetic controls. Sixty-six functionally impaired older persons aged 70+ with T2DM and 30 age and sex-matched controls were included in the analysis. We applied a partial least squares-discriminant analysis (PLS-DA)-based analytical strategy to characterize the metabotype of study participants. The optimal complexity of the PLS-DA model was found to be two latent variables. The proportion of correct classification was 94.1 ± 1.9% for frail/pre-frail persons with T2DM and 100% for control participants. Functionally impaired older persons with T2DM showed higher levels of 3-methyl histidine, alanine, arginine, glutamic acid, ethanolamine sarcosine, and tryptophan. Control participants had higher levels of ornithine and taurine. These findings indicate that a specific profile of amino acids and derivatives characterizes pre-frail/frail older persons with T2DM. The dissection of these pathways may provide novel insights into the metabolic perturbations involved in the disabling cascade in older persons with T2DM.

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