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Identification of candidate predictive and surrogate molecular markers for dasatinib in prostate cancer: rationale for patient selection and efficacy monitoring.

Authors
  • Wang, Xi-De
  • Reeves, Karen
  • Luo, Feng R
  • Xu, Li-An
  • Lee, Francis
  • Clark, Edwin
  • Huang, Fei
Type
Published Article
Publication Date
Jan 01, 2007
Volume
8
Issue
11
Identifiers
PMID: 18047674
Source
Medline
License
Unknown

Abstract

Using the gene expression profiling approach and preclinical models, we have identified prostatic biomarkers that are associated with sensitivity to dasatinib. This study has provided a basis for clinical evaluation of a potential dasatinib efficacy signature in prostate cancer.

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