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Identifiability: the first step in parameter estimation.

Authors
  • Jacquez, J A
Type
Published Article
Journal
Federation proceedings
Publication Date
Jun 01, 1987
Volume
46
Issue
8
Pages
2477–2480
Identifiers
PMID: 3595891
Source
Medline
Language
English
License
Unknown

Abstract

The observations in an experiment define a set of observational parameters that are functions of the basic kinetic parameters of the model of the system. The problem of identifiability is concerned with whether the observational parameters uniquely specify the basic kinetic parameters. As such, it depends only on the functional relation between the two levels of parameters and not on errors of observation and the estimation procedure. It should be checked before doing the experiment. Given initial estimates of the basic kinetic parameters, identifiability can be checked, in a local sense, from data generated by simulating the experiment on the model.

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