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Ideal versus corrected body weight for dosage of sugammadex in morbidly obese patients.

Authors
  • Van Lancker, P
  • Dillemans, B
  • Bogaert, T
  • Mulier, J P
  • De Kock, M
  • Haspeslagh, M
Type
Published Article
Journal
Anaesthesia
Publisher
Wiley (Blackwell Publishing)
Publication Date
Aug 01, 2011
Volume
66
Issue
8
Pages
721–725
Identifiers
DOI: 10.1111/j.1365-2044.2011.06782.x
PMID: 21692760
Source
Medline
License
Unknown

Abstract

To date, the dosing of sugammadex is based on real body weight without taking fat content into account. We compared the reversal of profound rocuronium-induced neuromuscular blockade in morbidly obese patients using doses of sugammadex based on four different weight corrections. One hundred morbidly obese patients, scheduled for laparoscopic bariatric surgery under propofol-sufentanil anaesthesia, were randomly assigned four groups: ideal body weight; ideal body weight + 20%; ideal body weight + 40%; and real body weight. Patients received sugammadex 2 mg.kg(-1), when adductor pollicis monitoring showed two responses. The primary endpoint was full decurarisation. Secondary endpoints were the ability to get into bed independently on arrival to the post-anaesthetic care unit and clinical signs of residual paralysis. There was no residual paralysis in any patient. Morbidly obese patients can safely be decurarised from rocuronium-induced neuromuscular blockade T1-T2 with sugammadex dosed at 2 mg.kg(-1) ideal body weight + 40% (p < 0.0001).

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