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Ichthyosis fetalis in Polled Hereford and Shorthorn calves.

Authors
  • O'Rourke, Brendon A1, 2, 3, 4
  • Kelly, Jillian1, 2, 3, 4
  • Spiers, Zoe B1, 2, 3, 4
  • Shearer, Patrick L1, 2, 3, 4
  • Porter, Naomi S1, 2, 3, 4
  • Parma, Pietro1, 2, 3, 4
  • Longeri, Maria1, 2, 3, 4
  • 1 New South Wales (NSW) Department of Primary Industries, Elizabeth Macarthur Agricultural Institute, Menangle, NSW, Australia (O'Rourke, Spiers, Shearer, Porter). , (Australia)
  • 2 Local Land Services, Coonamble, NSW, Australia (Kelly). , (Australia)
  • 3 Departments of Agricultural and Environmental Sciences, University of Milan, Milan, Italy (Parma). , (Italy)
  • 4 Veterinary Science and Public Health, University of Milan, Milan, Italy (Longeri). , (Italy)
Type
Published Article
Journal
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Publication Date
Nov 01, 2017
Volume
29
Issue
6
Pages
874–876
Identifiers
DOI: 10.1177/1040638717724186
PMID: 28782451
Source
Medline
Keywords
License
Unknown

Abstract

Inherited forms of ichthyosis, or generalized scaling of the skin, have been reported in many animal species, including cattle, and are characterized by an autosomal recessive mode of inheritance. We investigated 2 calves affected with ichthyosis fetalis, a Polled Hereford and a Shorthorn. Both cases had hard white plaques on the skin consistent with excessive keratinization. This was confirmed by histopathology, which showed severe diffuse epidermal and follicular orthokeratotic hyperkeratosis. The known mutation (H1935R) in gene ABCA12, responsible for ichthyosis fetalis in Chianina cattle, was shown to be absent in both affected calves and their obligate heterozygous parents. These molecular findings indicate that allelic heterogeneity exists for this condition in cattle.

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