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ICER-IIgamma is a tumor suppressor that mediates the antiproliferative activity of cAMP.

Authors
  • Razavi, R
  • Ramos, J C
  • Yehia, G
  • Schlotter, F
  • Molina, C A
Type
Published Article
Journal
Oncogene
Publisher
Springer Nature
Publication Date
Dec 10, 1998
Volume
17
Issue
23
Pages
3015–3019
Identifiers
PMID: 9881703
Source
Medline
License
Unknown

Abstract

The second messenger cAMP inhibits the proliferation of most cell types. The nuclear response of cAMP is mediated by transcription factors like the cAMP-Responsive Element Modulator (CREM) gene. One of the products of the CREM gene, the transcriptional repressor Inducible cAMP Early Repressor-IIgamma (ICER-IIgamma), is induced by cAMP. ICER-IIgamma blocks cells at the G2/M boundary of the cell cycle. Here we show that ICER-IIgamma dramatically inhibits the growth and DNA synthesis of mouse pituitary tumor cells and human choriocarcinoma cells. This alteration in cell growth is coupled with reduced ability of these cells to grow in an anchorage-independent manner and to form tumors in mice. These data demonstrate that ICER-IIgamma is a tumor suppressor gene product mediating the antiproliferative activity of cAMP.

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