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i(3)(q10) in non-Hodgkin's lymphoma (NHL)

Authors
  • Zamecnikova, Adriana
Publication Date
Dec 03, 2019
Source
I-Revues
Keywords
Language
English
License
Unknown
External links

Abstract

Partial or complete chromosome 3 gains resulting from the presence of trisomy 3, unbalanced translocation or isochromosome formation has been observed in different types of non-Hodgkin's lymphomas (NHL). Among them, the isochromosome of the long arm of chromosome 3 is a relatively rare chromosome aberration, associated mainly with B-cell NHL. However, its occurrence is not restricted to lymphomas, as the detection of +i(3)(q10) is considered a specific marker of polyclonal B-cell lymphocytosis with binucleated lymphocytes (PPBL) associated with an increase frequency of chromosome 3 instability as well as it may also be found in myeloid malignancies.

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