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Hypoxic-ischemic brain injury in neonatal piglets with different histological outcomes: An amplitude-integrated EEG study.

Authors
  • Zhang, Dandan
  • Hathi, Manan
  • Yang, Zeng-Jin
  • Ding, Haiyan
  • Koehler, Raymond
  • Thakor, Nitish
Type
Published Article
Journal
Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Publication Date
Jan 01, 2009
Volume
2009
Pages
1127–1130
Identifiers
DOI: 10.1109/IEMBS.2009.5333439
PMID: 19963989
Source
Medline
License
Unknown

Abstract

To test the reliability of amplitude-integrated electroencephalogram (aEEG) in cerebral hypoxic ischemia (HI), 12 neonatal piglets subjected to different levels of HI are divided into three groups based on the histological outcomes obtained 4 days after experiment. Results show that concomitant with the increased severity of brain injury, the upper and lower margins of aEEG decrease significantly (p < 0.05) during early recovery period after HI (about 2 hours post-resuscitation). We conclude that aEEG method reliably reflects hypoxic-ischemic cerebral injury and constitutes a valuable monitoring tool in neonatal intensive care unit (NICU).

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