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Hypoxic Gene Expression of Donor Bronchi Linked to Airway Complications after Lung Transplantation.

Authors
  • Kraft, Bryan D1
  • Suliman, Hagir B2
  • Colman, Eli C1
  • Mahmood, Kamran1
  • Hartwig, Matthew G3
  • Piantadosi, Claude A1, 2
  • Shofer, Scott L1
  • 1 1 Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
  • 2 2 Department of Anesthesiology, and.
  • 3 3 Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina.
Type
Published Article
Journal
American Journal of Respiratory and Critical Care Medicine
Publisher
American Thoracic Society
Publication Date
Mar 01, 2016
Volume
193
Issue
5
Pages
552–560
Identifiers
DOI: 10.1164/rccm.201508-1634OC
PMID: 26488115
Source
Medline
Keywords
License
Unknown

Abstract

These findings implicate donor bronchial hypoxia as a driving factor for post-transplantation airway complications. Strategies to improve airway oxygenation, such as bronchial artery re-anastomosis and hyperbaric oxygen therapy merit clinical investigation.

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