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Hypoxia Triggers the Intravasation of Clustered Circulating Tumor Cells

Authors
  • Donato, Cinzia1
  • Kunz, Leo2
  • Castro-Giner, Francesc1, 3
  • Paasinen-Sohns, Aino1
  • Strittmatter, Karin1
  • Szczerba, Barbara Maria1
  • Scherrer, Ramona1
  • Di Maggio, Nunzia4
  • Heusermann, Wolf5
  • Biehlmaier, Oliver5
  • Beisel, Christian2
  • Vetter, Marcus6, 7, 8
  • Rochlitz, Christoph7, 8
  • Weber, Walter Paul8, 9
  • Banfi, Andrea4
  • Schroeder, Timm2
  • Aceto, Nicola1
  • 1 Department of Biomedicine, Cancer Metastasis Laboratory, University of Basel and University Hospital Basel, 4058 Basel, Switzerland
  • 2 Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland
  • 3 SIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
  • 4 Department of Biomedicine, Cell and Gene Therapy Laboratory, University of Basel and University Hospital Basel, 4056 Basel, Switzerland
  • 5 IMCF Imaging Core Facility Biozentrum, University of Basel, 4056 Basel, Switzerland
  • 6 Gynecologic Cancer Center, University Hospital Basel, 4056 Basel, Switzerland
  • 7 Department of Medical Oncology, University Hospital Basel, 4056 Basel, Switzerland
  • 8 Breast Cancer Center, University Hospital Basel, 4056 Basel, Switzerland
  • 9 Department of Surgery, University of Basel and University Hospital Basel, 4056 Basel, Switzerland
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Sep 08, 2020
Volume
32
Issue
10
Identifiers
DOI: 10.1016/j.celrep.2020.108105
PMID: 32905777
PMCID: PMC7487783
Source
PubMed Central
License
Unknown

Abstract

Donato et al. show that intra-tumor hypoxia leads to cell-cell junction upregulation and formation of hypoxic CTC clusters with high metastatic ability. Treatment with EphrinB2 improves tumor vascularization and decreases hypoxia, leading to a reduced CTC cluster shedding rate and suppression of metastasis.

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