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Hypoxia related growth factors and p53 in preoperative sera from patients with colorectal cancer--evaluation of the prognostic significance of these agents.

Authors
  • Sulkowski, Stanislaw
  • Wincewicz, Andrzej
  • Zalewski, Bogdan
  • Famulski, Waldemar
  • Lotowska, Joanna Maria
  • Koda, Mariusz
  • Sobaniec-Lotowska, Maria Elzbieta
  • Mysliwiec, Michal
  • Baltaziak, Marek
  • Pawlak, Krystyna
  • Sulkowska, Mariola
Type
Published Article
Journal
Clinical Chemistry and Laboratory Medicine (CCLM)
Publisher
Walter de Gruyter GmbH
Publication Date
Jan 01, 2009
Volume
47
Issue
11
Pages
1439–1445
Identifiers
DOI: 10.1515/CCLM.2009.305
PMID: 19817649
Source
Medline
License
Unknown

Abstract

Comparisons between serum IGF-I and p53 appear to confirm the metabolism of p53 by IGF-I. Serum VEGF showed prognostic significance in our study. Serum concentrations of IGF-I and VEGF did not show positive correlation, as expected due to IGF-I induction of VEGF in malignant colon cell lines.

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