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[The hypoxia-inducible factor HIF as a new target in cancer research].

Authors
  • L'Allemain, Gilles
Type
Published Article
Journal
Bulletin du Cancer
Publisher
Elsevier
Publication Date
Mar 01, 2002
Volume
89
Issue
3
Pages
257–260
Identifiers
PMID: 11940464
Source
Medline
License
Unknown

Abstract

The vascular endothelial growth factors (VEGF) plays major roles during tumor development. VEGF expression is regulated by the transcription factor HIF (hypoxia inducible factor) which is very sensitive to oxygene variations. We will show here that HIF1alpha is today a good prognostic and diagnostic marker for an increasing number of cancers from various origins. Furthermore, the reduction of the expression or the activity of HIF1alpha impairs tumour angiogenesis and subsequently growth. Altogether, these results suggest that HIF1alpha could be an interesting target in cancer therapy.

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