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Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB.

Authors
  • Sonnweber, Thomas
  • Nachbaur, David
  • Schroll, Andrea
  • Nairz, Manfred
  • Seifert, Markus
  • Demetz, Egon
  • Haschka, David
  • Mitterstiller, Anna-Maria
  • Kleinsasser, Axel
  • Burtscher, Martin
  • Trübsbach, Susanne
  • Murphy, Anthony T
  • Wroblewski, Victor
  • Witcher, Derrick R
  • Mleczko-Sanecka, Katarzyna
  • Vecchi, Chiara
  • Muckenthaler, Martina U
  • Pietrangelo, Antonello
  • Theurl, Igor
  • Weiss, Günter
Type
Published Article
Journal
Gut
Publisher
BMJ
Publication Date
Dec 01, 2014
Volume
63
Issue
12
Pages
1951–1959
Identifiers
DOI: 10.1136/gutjnl-2013-305317
PMID: 24598129
Source
Medline
Keywords
License
Unknown

Abstract

Hypoxia decreases hepatic hepcidin expression by a novel regulatory pathway exerted via PDGF-BB, leading to increased availability of circulating iron that can be used for erythropoiesis.

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