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Hypothyroidism in patients treated with radiotherapy for head and neck carcinoma: standardised long-term follow-up study.

Authors
  • Alba, J R1
  • Basterra, J1
  • Ferrer, J C2
  • Santonja, F3
  • Zapater, E1
  • 1 Department of ENT,University General Hospital,Valencia Medical School,Spain. , (Spain)
  • 2 Department of Endocrinology,University General Hospital,Valencia Medical School,Spain. , (Spain)
  • 3 Department of Statistics and Operations Research,University of Valencia,Spain. , (Spain)
Type
Published Article
Journal
The Journal of Laryngology & Otology
Publisher
Cambridge University Press
Publication Date
May 01, 2016
Volume
130
Issue
5
Pages
478–481
Identifiers
DOI: 10.1017/S0022215116000967
PMID: 26975210
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Hypothyroidism is a common complication when radiotherapy is part of the treatment for head and neck tumours. This study aimed to show the incidence of hypothyroidism and possible risk factors in these patients. Factors related to the population, tumour, treatment and occurrence of hypothyroidism were analysed in 241 patients diagnosed with head and neck carcinoma. Approximately 53 per cent of patients were diagnosed with radiation-induced hypothyroidism. Its occurrence was related to: tumour location, laryngeal surgery type, neck dissection type, post-operative complications, cervical radiotherapy and radiotherapy unit type (linear particle accelerator or telecobalt therapy technology). Control of thyroid function should be standardised for several years after treatment, particularly in patients with risk factors, such as those treated with telecobalt therapy, those with post-operative complications and for whom the thyroid parenchyma is included in the irradiated area (laryngeal or pharyngeal location and bilateral cervical radiation).

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