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Hypothyroidism impairs the host immune response during the acute phase of Chagas disease.

Authors
  • Sampaio, Pedro Alexandre1
  • Goulart, Amanda2
  • Brazão, Vânia2
  • Anchieta, Naira Ferreira2
  • Providello, Maiara Voltarelli2
  • Portapilla, Gisele Bulhões2
  • Duarte, Andressa2
  • da Silva, Jefferson Luiz2
  • do Prado Júnior, José Clóvis2
  • 1 Department of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: [email protected] , (Brazil)
  • 2 Department of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. , (Brazil)
Type
Published Article
Journal
Immunobiology
Publication Date
Nov 01, 2020
Volume
225
Issue
6
Pages
152024–152024
Identifiers
DOI: 10.1016/j.imbio.2020.152024
PMID: 33227693
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Diseases associated with thyroid hypofunction have been the subject of studies in infectious models, since several authors have demonstrated a pivotal role of iodinated hormones (thyroxine and triiodothyronine) in the modulation of immune effector responses. Using a model of hypothyroidism induced by anti-thyroid drug, we investigated the influence of hypothyroidism in the course of acute Trypanosoma cruzi infection. For this, male Hannover Wistar rats were challenged with methimazole for 21 days (0.02% in drinking water), and water for control counterparts. After confirmation of the hypothyroidism, rats were intraperitoneally challenged with 1x105 blood trypomastigotes of the Y strain of T. cruzi. Our findings suggest that hypothyroidism impairs animal weight gain, but does not affect the health of essential organs. Interestingly, infected hypothyroid animals had a significant increase in thymic cell death, with consequent drop in lymphocyte frequency in whole blood (evaluated on the 11th day of infection). Analyzing the percentage of immune cells in the spleen, we found a strong influence of hypothyroidism as a negative regulator of B cells, and antigenic ability of macrophages (RT1b expression) in the course of the experimental chagasic infection. Enhanced serum IL-17A concentration was induced by T. cruzi infection, but hypothyroidism impaired the production of this mediator as seen in infected hypothyroid animals. Taken together, our work suggests for the first time that hypothyroidism may adversely interfere with the modulation of effective immunity in the early phase of Chagas' disease. Copyright © 2020 Elsevier GmbH. All rights reserved.

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