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Hypothalamic tanycytes generate acute hyperphagia through activation of the arcuate neuronal network.

Authors
  • Bolborea, Matei1
  • Pollatzek, Eric2
  • Benford, Heather2
  • Sotelo-Hitschfeld, Tamara2
  • Dale, Nicholas1
  • 1 School of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom [email protected] [email protected] , (United Kingdom)
  • 2 School of Life Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom. , (United Kingdom)
Type
Published Article
Journal
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Publication Date
Jun 23, 2020
Volume
117
Issue
25
Pages
14473–14481
Identifiers
DOI: 10.1073/pnas.1919887117
PMID: 32513737
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Hypothalamic tanycytes are chemosensitive glial cells that contact the cerebrospinal fluid in the third ventricle and send processes into the hypothalamic parenchyma. To test whether they can activate neurons of the arcuate nucleus, we targeted expression of a Ca2+-permeable channelrhodopsin (CatCh) specifically to tanycytes. Activation of tanycytes ex vivo depolarized orexigenic (neuropeptide Y/agouti-related protein; NPY/AgRP) and anorexigenic (proopiomelanocortin; POMC) neurons via an ATP-dependent mechanism. In vivo, activation of tanycytes triggered acute hyperphagia only in the fed state during the inactive phase of the light-dark cycle. Copyright © 2020 the Author(s). Published by PNAS.

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