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Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis.

Authors
  • Gorges, Martin1
  • Vercruysse, Pauline1, 2, 3
  • Müller, Hans-Peter1
  • Huppertz, Hans-Jürgen4
  • Rosenbohm, Angela1
  • Nagel, Gabriele5
  • Weydt, Patrick1
  • Petersén, Åsa6
  • Ludolph, Albert C3
  • Kassubek, Jan1
  • Dupuis, Luc2
  • 1 Department of Neurology, University of Ulm, Ulm, Germany. , (Germany)
  • 2 Faculté de Médecine, INSERM UMR-S1118, Strasbourg, France. , (France)
  • 3 Fédération de Médecine Translationnelle, Université de Strasbourg, Strasbourg, France. , (France)
  • 4 Swiss Epilepsy Centre, Klinik Lengg, Zurich, Switzerland. , (Switzerland)
  • 5 Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany. , (Germany)
  • 6 Department of Experimental Medical Sciences, Translational Neuroendocrine Research Unit, Lund University, Lund, Sweden. , (Sweden)
Type
Published Article
Journal
Journal of Neurology Neurosurgery & Psychiatry
Publisher
BMJ
Publication Date
Dec 01, 2017
Volume
88
Issue
12
Pages
1033–1041
Identifiers
DOI: 10.1136/jnnp-2017-315795
PMID: 28596251
Source
Medline
License
Unknown

Abstract

Hypothalamus is atrophied in ALS, even in premorbid stages, and correlates with BMI, especially in fALS. Decreased anterior hypothalamic volume is associated with earlier onset of disease.

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