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The hypotensive action of 3-deaza-adenosine.

Authors
  • Phyall, W
  • Chiang, P
  • Cantoni, G L
  • Lovenberg, W
Type
Published Article
Journal
European Journal of Pharmacology
Publisher
Elsevier
Publication Date
Oct 31, 1980
Volume
67
Issue
4
Pages
485–488
Identifiers
PMID: 7449828
Source
Medline
License
Unknown

Abstract

The effects of 3-deaza-adenosine on the cardiovascular system was investigated in normotensive (WKY) and spontaneously hypertensive rate (SHR). This compound (50 mg/kg i.p. 2X) significantly lowers blood pressure in both groups of animals, an effect which lasts for up to 2 h. The hypotensive effect is not affected by ganglion blockade, and appears to be due in part to a direct effect on blood vessels. While the response is similar to that seem with adenosine, it is more long-lasting. The results of this study suggest a potential role for this compound or analogues of its as possible antihypertensive agents.

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