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Hypotension in preterm infants with significant patent ductus arteriosus: effects of dopamine.

Authors
  • Bouissou, Antoine1
  • Rakza, Thameur
  • Klosowski, Serge
  • Tourneux, Pierre
  • Vanderborght, Marie
  • Storme, Laurent
  • 1 Department of Perinatal Medicine, Hôpital Jeanne de Flandre, CHRU Lille, France. , (France)
Type
Published Article
Journal
The Journal of pediatrics
Publication Date
Dec 01, 2008
Volume
153
Issue
6
Pages
790–794
Identifiers
DOI: 10.1016/j.jpeds.2008.06.014
PMID: 18675433
Source
Medline
Language
English
License
Unknown

Abstract

To study the effects of dopamine on systemic arterial pressure (SAP) and systemic blood flow (SBF) (estimated with the superior vena cava [SVC] flow) in preterm infants with hypotension and patent ductus arteriosus (PDA). Clinical and echocardiographic variables were measured before and 2 hours after starting dopamine in premature infants <32 weeks gestational age with PDA and systemic hypotension. Seventeen premature infants were included (gestational age, 28+/-2 weeks; birth weight, 1030 +/- 400 g). A mean rate of 8 +/- 2 microg/kg/min of dopamine raised SAP from 30 +/- 3 to 41 +/- 5 mm Hg (P < .05), and the pulmonary artery pressures from 25 +/- 5 to 32 +/- 8 mm Hg (P < .05). The SVC flow increased by 30% (from 130 +/- 40 to 170 +/- 44 mL/kg/min; P < .05). The left ventricular output and the end-diastolic and mean left pulmonary artery blood flow velocities did not change despite the increase in pulmonary artery pressure. In preterm infants with hypotension and PDA, dopamine (<10 microg/kg/min) increases the systemic blood pressure and the systemic blood flow. Our results suggest that dopamine decreases left-to-right shunting across ductus arteriosus, caused by a rise in pulmonary vascular resistances.

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