Affordable Access

deepdyve-link
Publisher Website

Hyposmotic challenge modulates function of L-type calcium channel in rat ventricular myocytes through protein kinase C.

Authors
  • Luo, An-tao
  • Luo, Hong-yan
  • Hu, Xin-wu
  • Gao, Lin-lin
  • Liang, Hua-min
  • Tang, Ming
  • Hescheler, Jürgen
Type
Published Article
Journal
Acta Pharmacologica Sinica
Publisher
Springer Nature
Publication Date
Nov 01, 2010
Volume
31
Issue
11
Pages
1438–1446
Identifiers
DOI: 10.1038/aps.2010.112
PMID: 20953210
Source
Medline
License
Unknown

Abstract

Hyposmotic challenge induced biphasic changes of I(Ca,L), a transient increase followed by a sustained decrease, in rat ventricular myocytes through PKC pathway, but not PKG pathway. PKA system could be responsible for the transient increase of I(Ca,L) during short exposure to hyposmotic solution.

Report this publication

Statistics

Seen <100 times