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Hypomethylation of ras oncogenes in primary human cancers.

Authors
  • Feinberg, A P
  • Vogelstein, B
Type
Published Article
Journal
Biochemical and biophysical research communications
Publication Date
Feb 28, 1983
Volume
111
Issue
1
Pages
47–54
Identifiers
PMID: 6187346
Source
Medline
License
Unknown

Abstract

We have examined the methylation status of two cellular oncogenes, c-Ha-ras and c-Ki-ras, in primary human carcinomas and the adjacent analogous normal tissues from which the tumors derived. The c-Ha-ras gene was hypomethylated in six of eight carcinomas, including five colonic adenocarcinomas and one small cell lung carcinoma, when compared to adjacent normal tissues. The c-Ki-ras gene was hypomethylated to a lesser extent in two colonic adenocarcinomas. This is the first demonstration of alterations in methylation of cellular oncogenes in human cancer.

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