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Hypogonadism in patients with acromegaly: data from the multi-centre acromegaly registry pilot study.

Authors
  • Katznelson, L
  • Kleinberg, D
  • Vance, M L
  • Stavrou, S
  • Pulaski, K J
  • Schoenfeld, D A
  • Hayden, D L
  • Wright, M E
  • Woodburn, C J
  • Klibanski, A
  • Stravou, S
Type
Published Article
Journal
Clinical endocrinology
Publication Date
Feb 01, 2001
Volume
54
Issue
2
Pages
183–188
Identifiers
PMID: 11207632
Source
Medline
License
Unknown

Abstract

We developed a web-based acromegaly patient registry and used it to show that hypogonadism is a frequent consequence of acromegaly, even in patients with microadenomas, who are not at risk from hypopituitarism due to local mass effects. We also demonstrated that prolactin and GH hypersecretion contribute to the pathogenesis of hypogonadism in acromegaly, and that hypogonadism may occur in microadenoma patients even in the absence of hyperprolactinaemia.

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