Affordable Access

Hyphae formation of Candida albicans is regulated by polyamines.

Authors
  • Ueno, Yukihiro
  • Fukumatsu, Makoto
  • Ogasawara, Ayako
  • Watanabe, Toshihiko
  • Mikami, Takeshi
  • Matsumoto, Tatsuzi
Type
Published Article
Journal
Biological & pharmaceutical bulletin
Publication Date
Jun 01, 2004
Volume
27
Issue
6
Pages
890–892
Identifiers
PMID: 15187439
Source
Medline
License
Unknown

Abstract

Candida albicans generally grows in hyphae form in RPMI1640 medium. However, addition of 1,4-diamino-2-butanone (DAB), a competitive inhibitor of ornithine decarboxylase, decreased the amount of polyamines in C. albicans, and induced the proliferation of the C. albicans yeast form. The expression of CYR1 mRNA was significantly inhibited by the addition of DAB compared with that of the control. The amount of intracellular cAMP was also decreased by the addition of DAB. A specific adenylate cyclase inhibitor, cis-N-[2-phenylcyclopentyl]-azacyclotridec-1-en-2-amine (MDL-12,330A) promoted the growth of the yeast form. These results indicated that polyamines exist upstream of the adenylate cyclase-cAMP signal pathway and regulate the transformation of C. albicans.

Report this publication

Statistics

Seen <100 times