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Hypertriglyceridemia—Causes, Significance, and Approaches to Therapy

Authors
  • Santos-Baez, Leinys S.
  • Ginsberg, Henry N.
Type
Published Article
Journal
Frontiers in Endocrinology
Publisher
Frontiers Media SA
Publication Date
Sep 02, 2020
Volume
11
Identifiers
DOI: 10.3389/fendo.2020.00616
PMID: 32982991
PMCID: PMC7492386
Source
PubMed Central
Keywords
License
Unknown

Abstract

Hypertriglyceridemia (HTG) is a common metabolic disorder with both genetic and lifestyle factors playing significant roles in its pathophysiology. HTG poses a risk for the development of cardiovascular disease (CVD) in the population at large and for pancreatitis in about two percent of individuals with extremely high levels of triglycerides (TG). This manuscript summarizes the mechanisms underlying the development of HTG as well as its management, including emerging therapies targeted at specific molecular pathways.

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