Many drugs for the treatment of hypertension are available in the United States today. Of the various factors that determine the appropriate treatment for a particular patient, the presence of concomitant heart disease requires specific tailoring of the antihypertensive therapy. Coronary artery disease, aortic insufficiency, congestive heart failure, left ventricular hypertrophy, premature ventricular contractions, supraventricular arrhythmias, mitral valve prolapse, orthostatic hypotension, and aortic dissection are some of the conditions that influence the choice of treatment. Diabetes places hypertensive patients at increased risk of heart disease, and exercise and sexual function are other considerations that govern the selection of treatment for the hypertensive person. For all of these conditions, more than one drug choice is often possible, but usually hypertensive patients can be treated with a beta-blocker or a calcium channel blocker in these special circumstances.