Affordable Access

Publisher Website

Hyperpolarized 13 C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco.

  • Crane, Jason C1
  • Gordon, Jeremy W1
  • Chen, Hsin-Yu1
  • Autry, Adam W1
  • Li, Yan1
  • Olson, Marram P1
  • Kurhanewicz, John1, 2
  • Vigneron, Daniel B1, 3
  • Larson, Peder E Z1
  • Xu, Duan1
  • 1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA.
  • 2 Department of Pharmaceutical Chemistry, University of California, San Francisco, USA.
  • 3 Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, USA.
Published Article
NMR in Biomedicine
Wiley (John Wiley & Sons)
Publication Date
Mar 19, 2020
DOI: 10.1002/nbm.4280
PMID: 32189442


Based on the expanding set of applications for hyperpolarized carbon-13 (HP-13 C) MRI, this work aims to communicate standardized methodology implemented at the University of California, San Francisco, as a primer for conducting reproducible metabolic imaging studies of the prostate and brain. Current state-of-the-art HP-13 C acquisition, data processing/reconstruction and kinetic modeling approaches utilized in patient studies are presented together with the rationale underpinning their usage. Organized around spectroscopic and imaging-based methods, this guide provides an extensible framework for handling a variety of HP-13 C applications, which derives from two examples with dynamic acquisitions: 3D echo-planar spectroscopic imaging of the human prostate and frequency-specific 2D multislice echo-planar imaging of the human brain. Details of sequence-specific parameters and processing techniques contained in these examples should enable investigators to effectively tailor studies around individual-use cases. Given the importance of clinical integration in improving the utility of HP exams, practical aspects of standardizing data formats for reconstruction, analysis and visualization are also addressed alongside open-source software packages that enhance institutional interoperability and validation of methodology. To facilitate the adoption and further development of this methodology, example datasets and analysis pipelines have been made available in the supporting information. © 2020 John Wiley & Sons, Ltd.

Report this publication


Seen <100 times