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Hypermutation in single-stranded DNA.

Authors
  • Saini, Natalie1
  • Gordenin, Dmitry A2
  • 1 Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, NC, USA.
  • 2 Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, NC, USA. Electronic address: [email protected]
Type
Published Article
Journal
DNA repair
Publication Date
Jan 01, 2020
Volume
91-92
Pages
102868–102868
Identifiers
DOI: 10.1016/j.dnarep.2020.102868
PMID: 32438271
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Regions of genomic DNA can become single-stranded in the course of normal replication and transcription as well as during DNA repair. Abnormal repair and replication intermediates can contain large stretches of persistent single-stranded DNA, which is extremely vulnerable to DNA damaging agents and hypermutation. Since such single-stranded DNA spans only a fraction of the genome at a given instance, hypermutation in these regions leads to tightly-spaced mutation clusters. This phenomenon of hypermutation in single-stranded DNA has been documented in several experimental models as well as in cancer genomes. Recently, hypermutated single-stranded RNA viral genomes also have been documented. Moreover, indications of hypermutation in single-stranded DNA may also be found in the human germline. This review will summarize key current knowledge and the recent developments in understanding the diverse mechanisms and sources of ssDNA hypermutation. Copyright © 2020 Elsevier B.V. All rights reserved.

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