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A hypermethylated phenotype is a better predictor of survival than MGMT methylation in anaplastic oligodendroglial brain tumors: a report from EORTC study 26951.

Authors
  • van den Bent, Martin J
  • Gravendeel, Lonneke A
  • Gorlia, Thierry
  • Kros, Johan M
  • Lapre, Lariesa
  • Wesseling, Pieter
  • Teepen, Johannes L
  • Idbaih, Ahmed
  • Sanson, Marc
  • Smitt, Peter A E Sillevis
  • French, Pim J
Type
Published Article
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Date
Nov 15, 2011
Volume
17
Issue
22
Pages
7148–7155
Identifiers
DOI: 10.1158/1078-0432.CCR-11-1274
PMID: 21914791
Source
Medline
License
Unknown

Abstract

The strong association between CIMP status and MGMT promoter methylation suggests that the MGMT promoter methylation status is part of a more general, prognostically favorable genome-wide methylation profile. Methylation profiling therefore may help identify AODs and AOAs with improved prognosis.

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