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Hyperlipidemia and noise in the chinchilla.

Authors
  • Morizono, T
  • Sikora, M A
  • Ward, W D
  • Paparella, M M
  • Jorgensen, J
Type
Published Article
Journal
Acta oto-laryngologica
Publication Date
Jan 01, 1985
Volume
99
Issue
5-6
Pages
516–524
Identifiers
PMID: 4024899
Source
Medline
License
Unknown

Abstract

Chinchillas were maintained on a 1% cholesterol diet for 6 months. Auditory Brainstem Response (ABR) measurements were obtained before and at 1, 3, 5, and 6 months after initiation of diet. Compound Action Potential (AP) measurements were obtained at sacrifice at 6 months. A significant reduction in ABR was seen at 5 months-on-diet. At 5 months, the animals were exposed to a 2 octave bandpass noise centered at 1 kHz at 105 dB for 220 min. One month following noise exposure, the cholesterol-fed animals exhibited a greater ABR latency shift at low intensities, and an elevated AP threshold at higher frequencies, vis-à-vis a control group.

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