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Hyperhomocysteinemia and Pulmonary Embolism in a Young Male.

Authors
  • Kovalenko, Olga1
  • Kassem, Ahmad N2
  • Jenkins, Melissa3
  • 1 Obstetrics and Gynecology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, USA.
  • 2 Internal Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, USA.
  • 3 Infectious Disease, MetroHealth Medical Center, Cleveland, USA.
Type
Published Article
Journal
Cureus
Publisher
Cureus, Inc.
Publication Date
Apr 24, 2020
Volume
12
Issue
4
Identifiers
DOI: 10.7759/cureus.7818
PMID: 32467793
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The association of hyperhomocysteinemia with thrombosis has provoked debate in the medical literature. Although studies have found associations between moderate homocysteine elevations and thrombotic events, others dispute this relationship. We present herein the case of a 24-year-old male who presented with unprovoked bilateral submassive pulmonary emboli. Extensive hypercoagulability workup was notable for an elevated homocysteine level, in addition to low vitamin B12 and folate levels. Of note, the patient had a history of small bowel resection after trauma, which may have contributed to the aforementioned metabolic derangements, potentially increasing his risk for thrombosis and interfering with the efficacy of his anticoagulation. Copyright © 2020, Kovalenko et al.

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