Affordable Access

deepdyve-link
Publisher Website

Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2

Authors
  • Reiterer, Moritz1
  • Rajan, Mangala2
  • Gómez-Banoy, Nicolás1
  • Lau, Jennifer D.2
  • Gomez-Escobar, Luis G.3
  • Ma, Lunkun1
  • Gilani, Ankit1
  • Alvarez-Mulett, Sergio3
  • Sholle, Evan T.4
  • Chandar, Vasuretha5
  • Bram, Yaron5
  • Hoffman, Katherine3
  • Bhardwaj, Priya2
  • Piloco, Phoebe2
  • Rubio-Navarro, Alfonso1
  • Uhl, Skyler6
  • Carrau, Lucia6
  • Houhgton, Sean7
  • Redmond, David7
  • Shukla, Alpana P.8
  • And 8 more
  • 1 Weill Center for Metabolic Health, Cardiovascular Research Institute, Division of Cardiology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA
  • 2 Department of Medicine, Weill Cornell Medicine, New York, NY, USA
  • 3 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA
  • 4 Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA
  • 5 Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA
  • 6 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  • 7 Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine, New York, NY, USA
  • 8 Weill Center for Metabolic Health, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Weill Cornell Medicine, New York, NY, USA
  • 9 Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA
  • 10 Division of Gastroenterology and Hepatology, Departments of Medicine and Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA
Type
Published Article
Journal
Cell Metabolism
Publisher
Elsevier Inc.
Publication Date
Sep 16, 2021
Identifiers
DOI: 10.1016/j.cmet.2021.09.009
PMID: 34599884
PMCID: PMC8443335
Source
PubMed Central
Keywords
Disciplines
  • Clinical and Translational Report
License
Unknown

Abstract

Here, Reiterer et al. report that hyperglycemia in critically ill patients with COVID-19 is caused mainly by insulin resistance and is associated with decreased circulating adiponectin. SARS-CoV-2 is shown to directly infect human adipocytes, trigger an inflammatory antiviral response in the adipose tissue, and cause its dysfunction.

Report this publication

Statistics

Seen <100 times