Affordable Access

Hypercalcemia in malignant paraganglioma due to parathyroid hormone-related protein.

Authors
  • Loh, K1
  • Matthay, K K
  • Hoover, M
  • Bracho, F A
  • Cortez, A B
  • Conte, F A
  • Albanese, C T
  • Miller, T R
  • Price, D C
  • Flores, A J
  • Kaviani, A
  • Shoback, D
  • 1 Division of Endocrinology and Metabolism, University of California, San Francisco, Calif., USA. [email protected]
Type
Published Article
Journal
Hormone research
Publication Date
Jan 01, 1998
Volume
50
Issue
4
Pages
217–221
Identifiers
PMID: 9838243
Source
Medline
License
Unknown

Abstract

A 15-year-old boy had hypercalcemia in association with malignant retroperitoneal paraganglioma. He had suppressed circulating levels of intact parathyroid hormone, whereas parathyroid hormone-related protein (PTHrP) immunoreactivity was elevated in plasma. Both the serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels were normal. Preoperatively the patient required control of hypercalcemia with intravenous pamidronate therapy. His circulating calcium and PTHrP concentrations became normal after a successful surgical resection of the primary retroperitoneal tumor. To our knowledge, this is the first reported case of elevated PtHrP levels in a patient with paraganglioma which resolved postoperatively.

Report this publication

Statistics

Seen <100 times