Affordable Access

Hypercalcemia complicating childhood malignancies: a report of seven cases with some pathophysiological considerations.

Authors
  • Harguindey, S
  • DeCastro, L
  • Barcos, M
  • Getaz, E P
  • Henderson, E S
  • Freeman, A
Type
Published Article
Journal
Cancer
Publication Date
Dec 01, 1979
Volume
44
Issue
6
Pages
2280–2290
Identifiers
PMID: 389412
Source
Medline
License
Unknown

Abstract

A group of seven children with different malignant processes presenting with hypercalcemia was studied. Bone destruction, diffuse metabolic abnormalities, abnormal acid-base homeostasis and recurrent hypercalcemia characterized these patients. A different mechanism leading to the production of hypercalcemia and/or bone destruction by cancer cells is considered. The results of this report suggest that parathyroid hormone production (P.T.H.) by the parathyroid glands is normal and that ectopic secretion of PTH or PTH-like material is negligible in these cases.

Report this publication

Statistics

Seen <100 times