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Hypercalcemia in childhood renal tumors.

Authors
  • Jayabose, S
  • Iqbal, K
  • Newman, L
  • San Filippo, J A
  • Davidian, M M
  • Noto, R
  • Sagel, I
Type
Published Article
Journal
Cancer
Publication Date
Feb 15, 1988
Volume
61
Issue
4
Pages
788–791
Identifiers
PMID: 2827881
Source
Medline
License
Unknown

Abstract

Hypercalcemia is an uncommon complication of childhood renal tumors. It is exclusively seen in infants 6 months of age or younger with malignant rhabdoid tumor of the kidney (MRTK) or congenital mesoblastic nephroma (CMN). Secretion of parathormone or prostaglandin E2 by the tumor cells is responsible for the hypercalcemia in most of these patients. Bone metastasis has been notably absent in these patients, and the hypercalcemia completely resolves with the removal of the tumor. Hypercalcemia in itself probably does not have any prognostic significance; however, it may serve as a tumor marker in some patients. Early recognition and effective management of this complication may prevent the acute life-threatening as well as the longstanding complications of this serious metabolic disorder.

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