With the use of the methodology of the system approach there were obtained results of the evaluation of the occurrence of ecology-dependent diseases in children and adolescents in bioclimatic zones of the Primorsky Krai. Analysis of the prevalence of the main classes of ecologically dependent diseases according to the appealability (diseases of the respiratory system, diseases of digestive organs, diseases of blood and blood-forming organs, diseases of the circulatory system, diseases of the skin and subcutaneous tissue, diseases of the genitourinary system, neoplasms, congenital anomalies, infectious diseases) was performed with the use of official statistical report forms No. 12 (ICD-10) over the period of2000-2014. Informational Database of parameters of the environment was represented by the factor modules: 6 - sanitary, and 5-environmental ones). By means of the method of the regression analysis there was established the relationship between environmental factors and the prevalence of ecological-dependent diseases, there were calculated values of the factor loads influencing on the indices of the morbidity rate in children and adolescents. The analysis of morbidity according to classes showed that during the study period, in the total there was a gain in the indicator ecologically dependent morbidity rate in children by 33.3%, in adolescents - by 35.3%. In the children and adolescent population there are prevalent diseases of the respiratory system - 67.3% and 52.45%, respectively; further in children and adolescent groups diseases of the digestive system - 9.45% and 17.08% take place; then in the children cohort are infectious diseases, and in adolescents - diseases of the genitourinary system. The level of ecologically dependent morbidity rate is determined by the complex impact of environmental and hygienic factors, with a predominance of sanitary-hygienic component and related with it parameters of the environment of habitation, such as chemical pollution of urban areas (soil, air, water sources), nevertheless biotropic factors (temperature, humidity, fog, number of days with biologically active solar radiation) make a significant contribution. The revealed various degree of the response of children and adolescents through the prevalence rate level to the exposure of ecological and hygienic factors of environment should be taken into account in the development and carrying out medical-preventive measures.