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Hydroxyurea interferes with antigen-dependent T-cell activation in vitro.

Authors
Type
Published Article
Journal
European journal of clinical investigation
Publication Date
Volume
30
Issue
2
Pages
162–166
Identifiers
PMID: 10651842
Source
Medline
License
Unknown

Abstract

Hydroxyurea inhibits antigen-induced lymphoproliferation in vitro at a concentration at which it does not inhibit PHA-induced HIV replication. Hydroxyurea may inhibit HIV-1 in CD4+ T cells in vivo not only by decreasing the amount of intracellular deoxynucleotides, but more specifically by interfering with antigen-dependent T-cell activation, thereby causing a reduction in the number of HIV target cells.

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