Affordable Access

deepdyve-link
Publisher Website

Hydroxyurea has the capacity to induce damage to human erythrocytes which can be modified by radical scavengers

Authors
  • Malec, J.
  • Przybyszewski, W.M.
  • Grabarczyk, M.
  • Sitarska, E.
Type
Published Article
Journal
Biochemical and Biophysical Research Communications
Publication Date
Jan 01, 1984
Volume
120
Issue
2
Pages
566–573
Identifiers
DOI: 10.1016/0006-291X(84)91292-0
Source
Elsevier
Keywords
License
Unknown

Abstract

The treatment of human erythrocytes with hydroxyurea /HU/ results in the azide-dependent changes in osmotic fragility and in increased methemoglobin formation. Similar changes were induced by H 2O 2 treatment. However when H 2O 2 in the presence of azide stimulated malondialdehyde production, in the HU-treated cells no malondialdehyde was detectable. When subjected to an oxidant stress /sodium ascorbate/ HU-treated erythrocytes were more fragile and revealed changes in the absorption spectrum of the TBA-reactive material in comparison with the cells treated with ascorbate alone. Partial protection by radical scavengers against certain HU-induced changes can be achieved. The results indicate that HU can damage erythrocytes and suggest the radical origin of these effects.

Report this publication

Statistics

Seen <100 times